Ercc4 | excision repair cross-complementing rodent repair deficiency, complementation group 4

GeneMGI:1354163Synonyms: Xpf

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Vision/eye Behavior/neurological Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:3Significant phenotypes
7Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased grip strength4 supporting datasetsErcc4em1(IMPC)JheterozygoteEarly adult5.79x10-9 
anophthalmia1 supporting datasetErcc4em1(IMPC)JhomozygoteE18.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetErcc4em1(IMPC)JhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ercc4em1(IMPC)JExon Deletionmouse
Ercc4tm43474(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Ercc4tm43474(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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