Hacd1 | 3-hydroxyacyl-CoA dehydratase 1

GeneMGI:1353592Synonyms: Ptpla

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Digestive/alimentary Vision/eye Craniofacial Cardiovascular system Mortality/aging

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



edema	1 supporting dataset	Hacd1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
cleft palate	1 supporting dataset	Hacd1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal skin morphology	1 supporting dataset	Hacd1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Hacd1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal placenta size	1 supporting dataset	Hacd1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Hacd1^em1(IMPC)Mbp	heterozygote	Early adult	1x10^-5
abnormal retina morphology	1 supporting dataset	Hacd1^em1(IMPC)Mbp	heterozygote	Early adult	2.83x10^-6
edema	1 supporting dataset	Hacd1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Hacd1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Hacd1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hacd1.

Associated images

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Histopathology

There is no histopathology data found for Hacd1.

IMPC related publications

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External links

No external links available for Hacd1.

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*Hacd1^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Hacd1^{tm48253(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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