Timm8a1 | translocase of inner mitochondrial membrane 8A1

GeneMGI:1353433Synonyms: Ddp1, Fci-12, +2 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system

15 No significant impact

7 Not tested

Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased blood urea nitrogen level1 supporting datasetTimm8a1em1(IMPC)TcphemizygoteEarly adult5.96x10-5 
decreased circulating total protein level1 supporting datasetTimm8a1em1(IMPC)TcphemizygoteEarly adult7.17x10-6 
increased red blood cell distribution width1 supporting datasetTimm8a1em1(IMPC)TcphomozygoteEarly adult4.91x10-5 
increased circulating alkaline phosphatase level1 supporting datasetTimm8a1em1(IMPC)TcphomozygoteEarly adult3.33x10-16 
increased circulating bilirubin level1 supporting datasetTimm8a1em1(IMPC)TcphomozygoteEarly adult2.44x10-5 
increased circulating alkaline phosphatase level1 supporting datasetTimm8a1em1(IMPC)TcphemizygoteEarly adult1.11x10-16 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Timm8a1em1(IMPC)TcpExon Deletionmouse
Timm8a1tm1(NCOM)CmhdReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell

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