Abcc2 | ATP-binding cassette, sub-family member 2

GeneMGI:1352447Synonyms: Mrp2, Cmoat, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Renal/urinary system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	9.63x10^-8
increased circulating bilirubin level	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.65x10^-174
increased circulating aspartate transaminase level	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.25x10^-6
increased circulating alanine transaminase level	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.05x10^-5
decreased mean platelet volume	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	8.84x10^-8
increased kidney weight	2 supporting datasets	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	3.18x10^-12
decreased lymphocyte cell number	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.91x10^-6
increased neutrophil cell number	2 supporting datasets	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	2.83x10^-8
decreased mean corpuscular volume	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	9.04x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Abcc2^{tm2b(KOMP)Wtsi}	homozygote	Early adult	4.8x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Abcc2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Abcc2.

IMPC related publications

Loading...

External links

No external links available for Abcc2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Abcc2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Abcc2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Abcc2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Abcc2^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Abcc2^{tm44698(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes