Prmt5 | protein arginine N-methyltransferase 5

GeneMGI:1351645Synonyms: Skb1, Jak-binding protein 1, +1 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Prmt5^{tm2a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Prmt5^{tm2a(EUCOMM)Wtsi}	heterozygote	Early adult	1.5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prmt5.

Associated images

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Histopathology

There is no histopathology data found for Prmt5.

IMPC related publications

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External links

No external links available for Prmt5.

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*Prmt5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Prmt5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Prmt5^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Prmt5^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Prmt5^{tm2c(EUCOMM)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Prmt5^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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