Abcb11 | ATP-binding cassette, sub-family B member 11

GeneMGI:1351619Synonyms: Bsep, PGY4, +4 more

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Respiratory system Behavior/neurological Mortality/aging

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.05x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.31x10^-5
increased circulating unsaturated transferrin level	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.78x10^-11
increased circulating alkaline phosphatase level	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.68x10^-19
abnormal lung morphology	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Abcb11^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.1x10^-5
increased circulating potassium level	1 supporting dataset	Abcb11^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.2x10^-10
decreased locomotor activity	2 supporting datasets	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.24x10^-6
abnormal retina morphology	1 supporting dataset	Abcb11^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.26x10^-7
increased circulating bilirubin level	1 supporting dataset	Abcb11^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.11x10^-98

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Abcb11.

Associated images

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Histopathology

There is no histopathology data found for Abcb11.

IMPC related publications

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External links

No external links available for Abcb11.

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*Abcb11^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Abcb11^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Abcb11^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Abcb11^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Abcb11^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Abcb11^{tm27268(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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