Dguok | deoxyguanosine kinase

GeneMGI:1351602Synonyms: dGK

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Reproductive system Adipose tissue Growth/size/body region Behavior/neurological Skeleton

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased bone mineral density1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult8.64x10-8 
abnormal locomotor behavior1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult6.99x10-6 
increased total body fat amount1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult6.49x10-6 
increased grip strength2 supporting datasetsDguokem1(IMPC)JhomozygoteEarly adult1.1x10-21 
increased bone mineral content1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult5.04x10-7 
decreased locomotor activity6 supporting datasetsDguokem1(IMPC)JhomozygoteEarly adult1.79x10-9 
decreased lean body mass1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult9.49x10-6 
decreased exploration in new environment1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult9.59x10-5 
female infertility1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Dguokem1(IMPC)JExon Deletionmouse
Dguoktm43098(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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