G3bp1 | G3BP stress granule assembly factor 1

GeneMGI:1351465Synonyms: GAP SH3 binding protein

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Nervous system Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Phy. System:



decreased total retina thickness	2 supporting datasets	G3bp1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.52x10^-6
preweaning lethality, incomplete penetrance	3 supporting datasets	G3bp1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	G3bp1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.51x10^-5
abnormal retina morphology	1 supporting dataset	G3bp1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.64x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for G3bp1.

Associated images

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Histopathology

There is no histopathology data found for G3bp1.

IMPC related publications

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External links

No external links available for G3bp1.

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*G3bp1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*G3bp1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*G3bp1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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