Grm6 | glutamate receptor, metabotropic 6

GeneMGI:1351343Synonyms: nob3, nerg1, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Behavior/neurological Cardiovascular system Renal/urinary system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



cataract	1 supporting dataset	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.59x10^-5
abnormal eye morphology	1 supporting dataset	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
hyperactivity	3 supporting datasets	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.55x10^-6
impaired pupillary reflex	1 supporting dataset	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.38x10^-22
increased kidney weight	2 supporting datasets	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.75x10^-10
increased heart weight	1 supporting dataset	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.26x10^-13
mydriasis	1 supporting dataset	Grm6^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.57x10^-22

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Grm6.

Associated images

Loading...

Histopathology

There is no histopathology data found for Grm6.

IMPC related publications

Loading...

External links

No external links available for Grm6.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Grm6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Grm6^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Grm6^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Grm6^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Grm6^{tm434(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes