Grm3 | glutamate receptor, metabotropic 3

GeneMGI:1351340Synonyms: mGluR3, 0710001G23Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Skeleton

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



microphthalmia	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.76x10^-5
decreased bone mineral content	2 supporting datasets	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.77x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.22x10^-5
impaired glucose tolerance	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.25x10^-5
decreased lean body mass	2 supporting datasets	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.23x10^-5
abnormal bone structure	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.48x10^-5
increased total body fat amount	2 supporting datasets	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.36x10^-6
increased circulating triglyceride level	1 supporting dataset	Grm3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.22x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Grm3.

Associated images

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Histopathology

There is no histopathology data found for Grm3.

IMPC related publications

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External links

No external links available for Grm3.

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*Grm3^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Grm3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Grm3^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Grm3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Grm3^{tm208463(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Grm3^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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