Pla2g10 | phospholipase A2, group X

GeneMGI:1347522Synonyms: mGXsPLA2, PLA2GX, +1 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal lens morphology	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.03x10^-9
cataract	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.76x10^-8
decreased heart rate	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.93x10^-6
increased heart rate variability	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.83x10^-9
cardiovascular system phenotype	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.66x10^-22
preweaning lethality, incomplete penetrance	1 supporting dataset	Pla2g10^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased mature B cell number	1 supporting dataset	Pla2g10^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	6.98x10^-5
prolonged QT interval	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.2x10^-14
abnormal QT variability	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.99x10^-18
prolonged RR interval	1 supporting dataset	Pla2g10^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.17x10^-26

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pla2g10.

Associated images

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Histopathology

There is no histopathology data found for Pla2g10.

IMPC related publications

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External links

No external links available for Pla2g10.

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*Pla2g10^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Pla2g10^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pla2g10^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pla2g10^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pla2g10^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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