Adamts6 | ADAM metallopeptidase with thrombospondin type 1 motif 6

GeneMGI:1347348Synonyms: b2b2228Clo, ADAM-TS6, +5 more

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Mortality/aging Craniofacial Cardiovascular system Renal/urinary system

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



cleft palate	1 supporting dataset	Adamts6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Adamts6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Adamts6^em1(IMPC)Mbp	heterozygote	Early adult	5.99x10^-5
abnormal blood vessel morphology	1 supporting dataset	Adamts6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Adamts6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Adamts6^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Adamts6^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Adamts6^em1(IMPC)Mbp	heterozygote	Early adult	6.35x10^-5
abnormal kidney morphology	1 supporting dataset	Adamts6^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal head shape	1 supporting dataset	Adamts6^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Adamts6.

Associated images

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Histopathology

There is no histopathology data found for Adamts6.

IMPC related publications

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External links

No external links available for Adamts6.

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*Adamts6^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Adamts6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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