Map3k12 | mitogen-activated protein kinase kinase kinase 12

GeneMGI:1346881Synonyms: Zpk, DLK, +1 more

Physiological systems

21 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Mortality/aging Cardiovascular system

19 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Map3k12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased heart left ventricle size	1 supporting dataset	Map3k12^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.84x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Map3k12.

Associated images

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Histopathology

There is no histopathology data found for Map3k12.

IMPC related publications

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External links

No external links available for Map3k12.

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*Map3k12^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Map3k12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Map3k12^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Map3k12^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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