Nelfa | negative elongation factor complex member A, Whsc2

GeneMGI:1346098Synonyms: Whsc2, Nelf-A, +1 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Integument Growth/size/body region Hematopoietic system Skeleton Mortality/aging Cardiovascular system Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Nelfa^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Nelfa^em1(IMPC)Tcp	homozygote	E15.5	N/A ^*
increased heart weight	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	6.94x10^-5
increased red blood cell distribution width	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	2.72x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Nelfa^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
abnormal skin morphology	2 supporting datasets	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Nelfa^em1(IMPC)Tcp	heterozygote	Early adult	1.22x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nelfa.

Associated images

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Histopathology

There is no histopathology data found for Nelfa.

IMPC related publications

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External links

No external links available for Nelfa.

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*Nelfa^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Nelfa^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Nelfa^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nelfa^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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