Aplnr | apelin receptor

GeneMGI:1346086Synonyms: apelin receptor, Agtrl1, +2 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Reproductive system Nervous system Vision/eye Mortality/aging Renal/urinary system

16 No significant impact

3 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance3 supporting datasetsAplnrtm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal kidney morphology1 supporting datasetAplnrtm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal epididymis morphology1 supporting datasetAplnrtm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
decreased prepulse inhibition1 supporting datasetAplnrtm1.1(KOMP)VlcgheterozygoteEarly adult8.53x10-6 
abnormal eye morphology1 supporting datasetAplnrtm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aplnrtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Aplnrtm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Aplnrtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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