Slc11a1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

GeneMGI:1345275Synonyms: Ity, Lsh, +6 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Integument Growth/size/body region Hematopoietic system

16 No significant impact

4 Not tested

Gene metrics:5Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal skin morphology2 supporting datasetsSlc11a1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal spleen morphology1 supporting datasetSlc11a1em1(IMPC)MbphomozygoteEarly adultN/A * 
enlarged spleen1 supporting datasetSlc11a1em1(IMPC)MbphomozygoteEarly adultN/A * 
increased neutrophil cell number1 supporting datasetSlc11a1em1(IMPC)MbphomozygoteEarly adult1.04x10-6 
decreased lymphocyte cell number1 supporting datasetSlc11a1em1(IMPC)MbphomozygoteEarly adult9.19x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Slc11a1em1(IMPC)MbpExon Deletionmouse
Slc11a1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Slc11a1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Slc11a1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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