Spry4 | sprouty RTK signaling antagonist 4

GeneMGI:1345144Synonyms: sprouty4, A030006O18Rik

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Vision/eye Behavior/neurological Skeleton

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	4 supporting datasets	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	4.03x10^-23
hyperactivity	2 supporting datasets	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	5.49x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.57x10^-12
abnormal cornea morphology	1 supporting dataset	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	4.24x10^-6
abnormal digit morphology	2 supporting datasets	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	5.15x10^-14
short tibia	2 supporting datasets	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	6.62x10^-8
cornea opacity	1 supporting dataset	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	4.24x10^-6
brachydactyly	1 supporting dataset	Spry4^{tm1b(KOMP)Mbp}	homozygote	Early adult	4.21x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Spry4.

Associated images

Loading...

Histopathology

There is no histopathology data found for Spry4.

IMPC related publications

Loading...

External links

No external links available for Spry4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Spry4^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Spry4^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Spry4^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

My Genes