Ldb3 | LIM domain binding 3

GeneMGI:1344412Synonyms: ZASP, cypher

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system Renal/urinary system

10 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
42Embryo tissues

Phenotypes

enlarged kidney1 supporting datasetLdb3tm2b(EUCOMM)HmguheterozygoteEarly adultN/A * 
increased basophil cell number1 supporting datasetLdb3tm2b(EUCOMM)HmguheterozygoteEarly adult1.39x10-5 
increased large unstained cell number2 supporting datasetsLdb3tm2b(EUCOMM)HmguheterozygoteEarly adult6.19x10-6 
small seminal vesicle1 supporting datasetLdb3tm2b(EUCOMM)HmguheterozygoteEarly adultN/A * 
prolonged QRS complex duration1 supporting datasetLdb3tm2b(EUCOMM)HmguheterozygoteEarly adult1.24x10-5 
decreased locomotor activity1 supporting datasetLdb3tm2b(EUCOMM)HmguheterozygoteEarly adult3.35x10-6 
preweaning lethality, complete penetrance1 supporting datasetLdb3tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ldb3tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ldb3tm2b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Ldb3tm2e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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