Grem2 | gremlin 2, DAN family BMP antagonist

GeneMGI:1344367Synonyms: Prdc

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Cardiovascular system Mortality/aging

18 No significant impact

4 Not tested

Gene metrics:3Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

dilated heart left ventricle3 supporting datasetsGrem2em1(IMPC)BayheterozygoteEarly adult3.59x10-6 
preweaning lethality, incomplete penetrance3 supporting datasetsGrem2em1(IMPC)BayhomozygoteEarly adultN/A * 
increased cardiac stroke volume1 supporting datasetGrem2em1(IMPC)BayheterozygoteEarly adult4.74x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Grem2em1(IMPC)BayExon Deletionmouse
Grem2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Grem2tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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