Grem2 | gremlin 2, DAN family BMP antagonist

GeneMGI:1344367Synonyms: Prdc

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Cardiovascular system Mortality/aging

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



dilated heart left ventricle	3 supporting datasets	Grem2^em1(IMPC)Bay	heterozygote	Early adult	3.59x10^-6
preweaning lethality, incomplete penetrance	3 supporting datasets	Grem2^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
increased cardiac stroke volume	1 supporting dataset	Grem2^em1(IMPC)Bay	heterozygote	Early adult	4.74x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Grem2.

Associated images

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Histopathology

There is no histopathology data found for Grem2.

IMPC related publications

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External links

No external links available for Grem2.

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*Grem2^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Grem2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Grem2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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