Arih1 | ariadne RBR E3 ubiquitin protein ligase 1

GeneMGI:1344363Synonyms: UIP77

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Integument Growth/size/body region Limbs/digits/tail Nervous system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	8 supporting datasets	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	5.35x10^-10
abnormal skin morphology	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Arih1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
short tibia	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	3.1x10^-5
abnormal sternum morphology	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
decreased prepulse inhibition	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	2.63x10^-7
embryonic lethality prior to organogenesis	1 supporting dataset	Arih1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
decreased anxiety-related response	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	7.76x10^-5
increased exploration in new environment	1 supporting dataset	Arih1^em1(IMPC)Tcp	heterozygote	Early adult	2.93x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arih1.

Associated images

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Histopathology

There is no histopathology data found for Arih1.

IMPC related publications

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External links

No external links available for Arih1.

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*Arih1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Arih1^{tm119275(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Arih1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Arih1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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