Emc8 | ER membrane protein complex subunit 8
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system Mortality/aging
12 No significant impact
5 Not tested
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| increased total body fat amount | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.7x10-6 | ||
| mydriasis | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.81x10-5 | ||
| enlarged heart | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | N/A * | ||
| increased neutrophil cell number | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.49x10-8 | ||
| increased red blood cell distribution width | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.72x10-8 | ||
| decreased lean body mass | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.73x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Emc8tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.2x10-5 |
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External links
No external links available for Emc8.
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| Emc8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Emc8tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Emc8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | es cell |