Pdk2 | pyruvate dehydrogenase kinase, isoenzyme 2

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Nervous system Vision/eye Liver/biliary system Hematopoietic system Renal/urinary system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal testis morphology	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged kidney	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged spleen	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
microphthalmia	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged testis	1 supporting dataset	Pdk2^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdk2.

Associated images

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Histopathology

There is no histopathology data found for Pdk2.

IMPC related publications

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External links

No external links available for Pdk2.

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*Pdk2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Pdk2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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