Pkig | protein kinase inhibitor, gamma

GeneMGI:1343086Synonyms: PKIgamma

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.35x10^-5
abnormal retina morphology	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.03x10^-8
increased startle reflex	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.04x10^-5
abnormal lens morphology	3 supporting datasets	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.11x10^-11
increased circulating alkaline phosphatase level	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.99x10^-8
increased circulating aspartate transaminase level	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.3x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.07x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.69x10^-6
irregularly shaped pupil	1 supporting dataset	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.13x10^-5
decreased total retina thickness	2 supporting datasets	Pkig^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.78x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pkig.

Associated images

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Histopathology

There is no histopathology data found for Pkig.

IMPC related publications

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External links

No external links available for Pkig.

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*Pkig^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pkig^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pkig^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Pkig^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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