Spop | speckle-type BTB/POZ protein

GeneMGI:1343085Synonyms: TEF2

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Nervous system Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	3 supporting datasets	Spop^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
small thymus	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
decreased prepulse inhibition	2 supporting datasets	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.08x10^-7
decreased grip strength	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.77x10^-5
decreased food intake	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.95x10^-5
enlarged lymph nodes	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
small adrenal glands	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
decreased respiratory quotient	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.17x10^-7
increased circulating aspartate transaminase level	1 supporting dataset	Spop^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.77x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spop.

Associated images

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Histopathology

There is no histopathology data found for Spop.

IMPC related publications

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External links

No external links available for Spop.

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*Spop^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Spop^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Spop^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Spop^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Spop^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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