Mthfd1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

GeneMGI:1342005Synonyms: E430024A07Rik, Mthfd, +1 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

18 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

3Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Mthfd1^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Mthfd1^{tm2b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
decreased circulating serum albumin level	1 supporting dataset	Mthfd1^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	3.54x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mthfd1.

Associated images

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Histopathology

There is no histopathology data found for Mthfd1.

IMPC related publications

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External links

No external links available for Mthfd1.

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*Mthfd1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mthfd1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Mthfd1^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mthfd1^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mthfd1^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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