Ggps1 | geranylgeranyl diphosphate synthase 1

GeneMGI:1341724Synonyms: 9530089B04Rik, GGPP synthase, +1 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Vision/eye Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating HDL cholesterol level	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.39x10^-7
abnormal vitreous body morphology	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.74x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.48x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal lens morphology	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.55x10^-5
increased circulating glucose level	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.85x10^-5
abnormal coat/ hair morphology	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.62x10^-6
increased circulating cholesterol level	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.6x10^-6
cataract	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.17x10^-5
increased leukocyte cell number	1 supporting dataset	Ggps1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.58x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ggps1.

Associated images

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Histopathology

There is no histopathology data found for Ggps1.

IMPC related publications

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External links

No external links available for Ggps1.

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*Ggps1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Ggps1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ggps1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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