Mmp13 | matrix metallopeptidase 13

GeneMGI:1340026Synonyms: MMP-13, interstitial collagenase, +4 more

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
prolonged QT interval	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.97x10^-6
decreased heart rate	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.82x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.44x10^-7
short tibia	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.72x10^-8
enlarged thymus	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
prolonged RR interval	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.3x10^-5
decreased circulating sodium level	1 supporting dataset	Mmp13^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.41x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmp13.

Associated images

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Histopathology

There is no histopathology data found for Mmp13.

IMPC related publications

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External links

No external links available for Mmp13.

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*Mmp13^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse

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