Bhmt | betaine-homocysteine methyltransferase

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system

13 No significant impact

6 Not tested

Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues

Phenotypes

increased lean body mass2 supporting datasetsBhmttm1b(EUCOMM)HmguhomozygoteEarly adult2.63x10-7 
decreased total body fat amount1 supporting datasetBhmttm1b(EUCOMM)HmguhomozygoteEarly adult8.7x10-6 
decreased blood urea nitrogen level1 supporting datasetBhmttm1b(EUCOMM)HmguhomozygoteEarly adult2.2x10-5 
increased spleen weight1 supporting datasetBhmttm1b(EUCOMM)HmguhomozygoteEarly adult3.41x10-5 
decreased hemoglobin content1 supporting datasetBhmttm1b(EUCOMM)HmguhomozygoteEarly adult7.25x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bhmttm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Bhmttm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Bhmttm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Bhmttm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Bhmttm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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