Myh8 | myosin, heavy polypeptide 8, skeletal muscle, perinatal

GeneMGI:1339712Synonyms: Myhs-p, Myhsp, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Skeleton Mortality/aging Renal/urinary system

14 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsMyh8em1(IMPC)TcphomozygoteEarly adultN/A * 
edema1 supporting datasetMyh8em1(IMPC)TcphomozygoteE15.5N/A * 
abnormal sternum morphology1 supporting datasetMyh8em1(IMPC)TcpheterozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetMyh8em1(IMPC)TcphomozygoteE15.5N/A * 
decreased hematocrit1 supporting datasetMyh8em1(IMPC)TcpheterozygoteEarly adult2.35x10-7 
enlarged urinary bladder1 supporting datasetMyh8em1(IMPC)TcpheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Myh8em1(IMPC)TcpExon Deletionmouse
Myh8tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Myh8tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Myh8tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Myh8tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
Myh8tm2e(KOMP)MbpTargeted, non-conditional alleleES Cell

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