Acvr1b | activin A receptor, type 1B

GeneMGI:1338944Synonyms: SKR2, Acvrlk4, +3 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

1Associated diseases

Expression examined in:41Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



small adrenal glands	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal coat/ hair morphology	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.49x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Acvr1b^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Acvr1b^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Acvr1b.

Associated images

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Histopathology

There is no histopathology data found for Acvr1b.

IMPC related publications

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External links

No external links available for Acvr1b.

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*Acvr1b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Acvr1b^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Acvr1b^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Acvr1b^{tm442836(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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