Mthfd2 | methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

GeneMGI:1338850Synonyms: NMDMC

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Integument Embryo Growth/size/body region Vision/eye Liver/biliary system Behavior/neurological Skeleton Cardiovascular system Mortality/aging Craniofacial

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	2 supporting datasets	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal umbilical cord morphology	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
thick ventricular wall	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.09x10^-5
increased heart left ventricle size	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.81x10^-5
abnormal craniofacial morphology	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
abnormal facial morphology	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
abnormal placenta size	1 supporting dataset	Mthfd2^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mthfd2.

Associated images

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Histopathology

There is no histopathology data found for Mthfd2.

IMPC related publications

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External links

No external links available for Mthfd2.

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*Mthfd2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mthfd2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mthfd2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Mthfd2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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