Irag1 | inositol 1,4,5-triphosphate receptor associated 1

GeneMGI:1338023Synonyms: Mrvi1, Ris1

Physiological systems

23 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:27Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal spleen morphology	2 supporting datasets	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal cecum morphology	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased total body fat amount	2 supporting datasets	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.92x10^-12
enlarged spleen	2 supporting datasets	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged cecum	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small heart	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased freezing behavior	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.7x10^-6
increased mean corpuscular volume	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.83x10^-19
small seminal vesicle	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased eosinophil cell number	1 supporting dataset	Irag1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Irag1.

Associated images

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Histopathology

There is no histopathology data found for Irag1.

IMPC related publications

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External links

No external links available for Irag1.

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*Irag1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Irag1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Irag1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Irag1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Irag1^{tm80032(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Irag1^{tm83448(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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