Ap4e1 | adaptor-related protein complex AP-4, epsilon 1

GeneMGI:1336993Synonyms: 2310033A20Rik

Physiological systems

24 / 24 physiological systems tested

17 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Adipose tissue Growth/size/body region Muscle Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological Skeleton Mortality/aging

7 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:74Significant phenotypes

3Associated diseases

Expression examined in:158Adult tissues

59Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



decreased total body fat amount	10 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.88x10^-14
abnormal lens morphology	4 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.28x10^-7
increased red blood cell distribution width	1 supporting dataset	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.1x10^-5
small testis	2 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased anxiety-related response	1 supporting dataset	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.48x10^-7
decreased mean corpuscular volume	1 supporting dataset	Ap4e1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.4x10^-21
abnormal sleep behavior	8 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.81x10^-9
decreased grip strength	3 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.68x10^-7
hyperactivity	28 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.19x10^-14
abnormal testis morphology	2 supporting datasets	Ap4e1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ap4e1.

Associated images

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Histopathology

There is no histopathology data found for Ap4e1.

IMPC related publications

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External links

No external links available for Ap4e1.

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*Ap4e1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Ap4e1^em1(IMPC)J*	Indel	‌	mouse
*Ap4e1^em2(IMPC)Mbp*	Indel	‌	mouse
*Ap4e1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ap4e1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ap4e1^{tm1c(KOMP)Wtsi}*	Wild type floxed exon (post-Flp)	‌	mouse
*Ap4e1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Ap4e1^{tm35132(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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