Prkaa2 | protein kinase, AMP-activated, alpha 2 catalytic subunit

GeneMGI:1336173Synonyms: 2310008I11Rik, AMPKalpha2

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased mean platelet volume	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.42x10^-6
decreased circulating fructosamine level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.12x10^-7
decreased exploration in new environment	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.53x10^-5
decreased circulating alkaline phosphatase level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.72x10^-5
decreased fasting circulating glucose level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.09x10^-7
increased circulating creatine kinase level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.07x10^-5
enlarged spleen	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased circulating serum albumin level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.62x10^-6
increased circulating aspartate transaminase level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.67x10^-42
increased circulating alanine transaminase level	1 supporting dataset	Prkaa2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.83x10^-23

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prkaa2.

Associated images

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Histopathology

There is no histopathology data found for Prkaa2.

IMPC related publications

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External links

No external links available for Prkaa2.

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*Prkaa2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Prkaa2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Prkaa2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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