Prkab1 | protein kinase, AMP-activated, beta 1 non-catalytic subunit

GeneMGI:1336167Synonyms: 1300015D22Rik

Physiological systems

24 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging Renal/urinary system

11 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:64Significant phenotypes

0Associated diseases

Expression examined in:158Adult tissues

58Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	9 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased spleen weight	4 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.46x10^-23
enlarged spleen	2 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased total retina thickness	4 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.28x10^-14
decreased erythrocyte cell number	1 supporting dataset	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.94x10^-5
increased red blood cell distribution width	6 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.75x10^-80
increased neutrophil cell number	1 supporting dataset	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.68x10^-7
decreased mean corpuscular hemoglobin	9 supporting datasets	Prkab1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	0
decreased mean corpuscular volume	1 supporting dataset	Prkab1^em1(IMPC)J	homozygote	Early adult	0
preweaning lethality, incomplete penetrance	1 supporting dataset	Prkab1^{Gt(RRR454)Byg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prkab1.

Associated images

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Histopathology

There is no histopathology data found for Prkab1.

IMPC related publications

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External links

No external links available for Prkab1.

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*Prkab1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Prkab1^em1(IMPC)J*	Exon Deletion	‌	mouse
*Prkab1^em2(IMPC)Mbp*	Indel	‌	mouse
*Prkab1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Prkab1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Prkab1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Prkab1^{tm301228(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Prkab1^{tm37294(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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