Heph | hephaestin

GeneMGI:1332240Synonyms: sla, Cpl, +2 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Cardiovascular system

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal lymph node morphology	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	1.25x10^-5
increased circulating phosphate level	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.68x10^-6
abnormal lymph node morphology	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	6.09x10^-12
abnormal heart morphology	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.49x10^-8
enlarged lymph nodes	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Heph^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Heph.

Associated images

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Histopathology

There is no histopathology data found for Heph.

IMPC related publications

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External links

No external links available for Heph.

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*Heph^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Heph^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Heph^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Heph^{tm358271(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Heph^{tm41087(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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