Trpm1 | transient receptor potential cation channel, subfamily M, member 1

GeneMGI:1330305Synonyms: LTRPC1, melastatin, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



impaired glucose tolerance	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.54x10^-7
increased circulating creatine kinase level	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.16x10^-5
mydriasis	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.57x10^-22
impaired pupillary reflex	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.57x10^-22
increased circulating HDL cholesterol level	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.93x10^-5
limb grasping	1 supporting dataset	Trpm1^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.69x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Trpm1.

Associated images

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Histopathology

There is no histopathology data found for Trpm1.

IMPC related publications

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External links

No external links available for Trpm1.

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*Trpm1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Trpm1^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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