Tulp3 | TUB like protein 3

GeneMGI:1329045Synonyms: 2310022L06Rik

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Behavior/neurological Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.62x10^-11
increased total body fat amount	2 supporting datasets	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.8x10^-6
decreased fasting circulating glucose level	1 supporting dataset	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.83x10^-6
decreased prepulse inhibition	3 supporting datasets	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.59x10^-8
abnormal response to new environment	1 supporting dataset	Tulp3^hhkr	heterozygote	Early adult	2.04x10^-5
increased circulating bilirubin level	1 supporting dataset	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.42x10^-15
preweaning lethality, complete penetrance	1 supporting dataset	Tulp3^hhkr	homozygote	Early adult	N/A ^*
decreased lean body mass	2 supporting datasets	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.21x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Tulp3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.52x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Tulp3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tulp3.

Associated images

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Histopathology

There is no histopathology data found for Tulp3.

IMPC related publications

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External links

No external links available for Tulp3.

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*Tulp3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tulp3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tulp3^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Tulp3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Tulp3^{tm43124(L1L2_gt2)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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