Cdk9 | cyclin dependent kinase 9

GeneMGI:1328368Synonyms: PITALRE

Physiological systems

22 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Reproductive system Behavior/neurological Mortality/aging

19 No significant impact

2 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
30Embryo tissues

Phenotypes

enlarged epididymis1 supporting datasetCdk9tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance3 supporting datasetsCdk9tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to tooth bud stage1 supporting datasetCdk9tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
abnormal epididymis morphology1 supporting datasetCdk9tm1.1(KOMP)VlcgheterozygoteEarly adultN/A * 
increased vertical activity1 supporting datasetCdk9tm1.1(KOMP)VlcgheterozygoteEarly adult1.9x10-6 
embryonic lethality prior to organogenesis1 supporting datasetCdk9tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cdk9tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Cdk9tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Cdk9tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Cdk9tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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