Hint1 | histidine triad nucleotide binding protein 1

GeneMGI:1321133Synonyms: PKC inhibitor/ interacting protein, Ipk1, +3 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system Behavior/neurological

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased erythrocyte cell number1 supporting datasetHint1tm1a(EUCOMM)WtsihomozygoteEarly adult5.6x10-5 
increased startle reflex3 supporting datasetsHint1tm1a(EUCOMM)WtsihomozygoteEarly adult6.04x10-8 
tremors1 supporting datasetHint1tm1a(EUCOMM)WtsihomozygoteEarly adult2.05x10-6 
decreased circulating glycerol level1 supporting datasetHint1tm1a(EUCOMM)WtsihomozygoteEarly adult3.01x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hint1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Hint1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Hint1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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