Slit2 | slit guidance ligand 2

GeneMGI:1315205Synonyms: E130320P19Rik, E030015M03Rik, +3 more

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Embryo Growth/size/body region Vision/eye Mortality/aging Cardiovascular system Renal/urinary system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged kidney	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Slit2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
cataract	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	Early adult	6.35x10^-5
abnormal placenta morphology	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
hydrometra	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Slit2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	Early adult	5.99x10^-5
abnormal placenta morphology	1 supporting dataset	Slit2^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
microphthalmia	1 supporting dataset	Slit2^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slit2.

Associated images

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Histopathology

There is no histopathology data found for Slit2.

IMPC related publications

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External links

No external links available for Slit2.

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*Slit2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Slit2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Slit2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Slit2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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