Hipk3 | homeodomain interacting protein kinase 3

GeneMGI:1314882Synonyms: FIST3, DYRK6

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	2 supporting datasets	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.93x10^-8
decreased prepulse inhibition	4 supporting datasets	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.8x10^-7
decreased locomotor activity	6 supporting datasets	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.23x10^-8
increased heart rate variability	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.8x10^-7
thrombocytosis	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.4x10^-5
decreased heart rate	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.94x10^-7
increased circulating alanine transaminase level	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.14x10^-5
prolonged RR interval	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.49x10^-8
decreased startle reflex	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.29x10^-8
increased mean platelet volume	1 supporting dataset	Hipk3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.21x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hipk3.

Associated images

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Histopathology

There is no histopathology data found for Hipk3.

IMPC related publications

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External links

No external links available for Hipk3.

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*Hipk3^{em1(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Hipk3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hipk3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hipk3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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