Hipk2 | homeodomain interacting protein kinase 2

GeneMGI:1314872Synonyms: 1110014O20Rik, Stank, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Growth/size/body region Vision/eye Skeleton Craniofacial Cardiovascular system Mortality/aging Renal/urinary system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal tooth morphology	3 supporting datasets	Hipk2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	1.52x10^-6
abnormal snout morphology	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	4.9x10^-5
abnormal lens morphology	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	9.54x10^-6
increased kidney weight	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.85x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal maxilla morphology	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	3.08x10^-5
increased heart weight	1 supporting dataset	Hipk2^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hipk2.

Associated images

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Histopathology

There is no histopathology data found for Hipk2.

IMPC related publications

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External links

No external links available for Hipk2.

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*Hipk2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Hipk2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Hipk2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Hipk2^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hipk2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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