Dnase1l3 | deoxyribonuclease 1-like 3

GeneMGI:1314633Synonyms: DNasegamma

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged spleen	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	8.92x10^-5
abnormal spleen morphology	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
cataract	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	6.42x10^-5
abnormal testis morphology	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	5.72x10^-6
microphthalmia	1 supporting dataset	Dnase1l3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnase1l3.

Associated images

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Histopathology

There is no histopathology data found for Dnase1l3.

IMPC related publications

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External links

No external links available for Dnase1l3.

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*Dnase1l3^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dnase1l3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dnase1l3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Dnase1l3^{tm42548(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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