Krt34 | keratin 34

GeneMGI:1309994Synonyms: 4733401E01Rik, Krt1-4

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.96x10^-6
enlarged heart	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased kidney weight	2 supporting datasets	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.46x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.72x10^-5
abnormal spleen morphology	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Krt34^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Krt34.

Associated images

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Histopathology

There is no histopathology data found for Krt34.

IMPC related publications

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External links

No external links available for Krt34.

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*Krt34^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Krt34^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Krt34^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Krt34^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Krt34^{tm357090(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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