Dhx8 | DEAH-box helicase 8

GeneMGI:1306823Synonyms: Ddx8, RNA helicase, +1 more

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Hematopoietic system Mortality/aging Renal/urinary system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal retina morphology	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	8.04x10^-5
microphthalmia	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal vitreous body morphology	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	5.12x10^-6
decreased prepulse inhibition	3 supporting datasets	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	2.49x10^-6
abnormal spleen morphology	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small kidney	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Dhx8^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Dhx8^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dhx8.

Associated images

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Histopathology

There is no histopathology data found for Dhx8.

IMPC related publications

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External links

No external links available for Dhx8.

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*Dhx8^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dhx8^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Dhx8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dhx8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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