Bscl2 | BSCL2 lipid droplet biogenesis associated, seipin

GeneMGI:1298392Synonyms: Gng3lg, seipin

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:32Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lean body mass	4 supporting datasets	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
increased mean corpuscular volume	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.28x10^-35
increased circulating total protein level	2 supporting datasets	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
increased large unstained cell number	2 supporting datasets	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.03x10^-6
abnormal gait	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.29x10^-9
increased mean corpuscular hemoglobin	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.44x10^-13
increased fasting circulating glucose level	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.44x10^-14
increased circulating calcium level	2 supporting datasets	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	0
decreased bone mineral content	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.65x10^-5
increased circulating glucose level	1 supporting dataset	Bscl2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.73x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bscl2.

Associated images

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Histopathology

There is no histopathology data found for Bscl2.

IMPC related publications

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External links

No external links available for Bscl2.

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*Bscl2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Bscl2^em2(IMPC)H*	Exon Deletion	‌	mouse
*Bscl2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bscl2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bscl2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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