Itgae | integrin alpha E, epithelial-associated

GeneMGI:1298377Synonyms: CD103, alpha-E1

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Growth/size/body region Hematopoietic system

15 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

decreased lean body mass2 supporting datasetsItgaetm1b(EUCOMM)WtsihomozygoteEarly adult2.14x10-7 
decreased monocyte cell number1 supporting datasetItgaetm1b(EUCOMM)WtsihomozygoteEarly adult3.74x10-6 
decreased leukocyte cell number1 supporting datasetItgaetm1b(EUCOMM)WtsihomozygoteEarly adult2.59x10-9 
decreased lymphocyte cell number1 supporting datasetItgaetm1b(EUCOMM)WtsihomozygoteEarly adult7.5x10-8 
decreased neutrophil cell number1 supporting datasetItgaetm1b(EUCOMM)WtsihomozygoteEarly adult1.98x10-7 
decreased large unstained cell number1 supporting datasetItgaetm1b(EUCOMM)WtsihomozygoteEarly adult3.3x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Itgaetm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Itgaetm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Itgaetm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Itgaetm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Itgaetm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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