Cnot7 | CCR4-NOT transcription complex, subunit 7

GeneMGI:1298230Synonyms: Caf1

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Adipose tissue Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal kidney morphology	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
decreased anxiety-related response	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Early adult	1.98x10^-5
small testis	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
increased lean body mass	2 supporting datasets	Cnot7^{em1(IMPC)Rbrc}	homozygote	Early adult	7.81x10^-7
enlarged heart	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
enlarged kidney	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
small ovary	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Late adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Cnot7^{em1(IMPC)Rbrc}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cnot7.

Associated images

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Histopathology

There is no histopathology data found for Cnot7.

IMPC related publications

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External links

No external links available for Cnot7.

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*Cnot7^{em1(IMPC)Rbrc}*	Exon Deletion	‌	mouse
*Cnot7^{em2(IMPC)Rbrc}*	Exon Deletion	‌	mouse
*Cnot7^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cnot7^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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