Pip5k1c | phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

GeneMGI:1298224Synonyms: PIP5KIgamma

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

17 No significant impact

3 Not tested

Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:55Adult tissues
50Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetPip5k1ctm1b(KOMP)WtsihomozygoteEarly adultN/A * 
increased circulating alkaline phosphatase level1 supporting datasetPip5k1ctm1b(KOMP)WtsiheterozygoteEarly adult4.11x10-7 
edema1 supporting datasetPip5k1ctm1b(KOMP)WtsihomozygoteE18.5N/A * 
persistence of hyaloid vascular system1 supporting datasetPip5k1ctm1b(KOMP)WtsiheterozygoteEarly adult1.02x10-5 
decreased grip strength1 supporting datasetPip5k1ctm1b(KOMP)WtsiheterozygoteEarly adult4.02x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

adrenal glandheterozygoteSection images
50% (2/4)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
blood vesselheterozygoten/a0% (0/2)0% (0/173)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoteSection images
100% (4/4)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/4)0% (0/588)
cartilage tissueheterozygoteSection images
50% (2/4)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
Download adult data as:  
Rows per page: 

Human diseases caused by Pip5k1c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






Download data as:  

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Pip5k1ctm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pip5k1ctm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter